慢性复发性腮腺炎的唾液腺内镜治疗

慢性复发性腮腺炎的病因目前尚不清楚,临床表现为单侧或者双侧腮腺的反复肿痛,可以伴或者不伴发热。唾液腺造影以及超声检查,可以发现唾液分泌滞留的情况。

有病理组织学报道发现其发展可以分为三个阶段:

  • 初期的腮腺实质和腺小叶结构正常,导管周围可见少量淋巴细胞和浆细胞浸润;
  • 进一步发展,导管周围的炎症表现会加重,浸润的淋巴细胞甚至形成滤泡装结构;
  • 在最终的“immunologic”阶段,腺体实质被淋巴组织取代,腺体结构破坏。

既往对于这种疾病的治疗主要是保守对症治疗,如促进唾液分泌、按摩以及使用抗生素等。

唾液腺内窥镜出现以后,有大量使用内窥镜进行灌洗及导管扩张来治疗慢性复发性腮腺炎的报道。治疗程序及方法大致如下(以本文参考资料中的方法为例):

  1. The gland was thoroughly lavaged with approximately 60 mL of normal saline solution (each side).
  2. The sialoendoscope was also used to dilate the duct with hydrostatic pressure; in 4 patients, a high-pressure dilatation balloon was used, and in another 4 patients, a microdrill (300 微米) was used to open strictures.
  3. After lavage and dilatation, hydrocortisone (100 mg) was injected via the endoscope into the gland. (也有同时使用hydrocortisone 和Rifocin (250mg/3ml)进行灌洗)
  4. After the procedure, all of the patients were given intravenous Augmentin (amoxicillin and clavulanic acid, 25 mg/kg; GlaxoSmithKline, Worthing, West Sussex, UK) and dexamethasone.
  5. Follow-up was performed through at least 12 months after surgery.

类似的治疗程序也不仅仅用于慢性复发性腮腺炎,在其他慢性唾液腺炎的治疗中也有应用,治疗效果尚无统计。兹做记录,供临床参考。

参考资料:

  1. Shacham R, Droma EB, London D, Bar T, Nahlieli O. Long-term experience with endoscopic diagnosis and treatment of juvenile recurrent parotitis. J Oral Maxillofac Surg. 2009 Jan;67(1):162-7. doi: 10.1016/j.joms.2008.09.027. PMID: 19070763.
本文链接地址:https://omssurgeon.com/2128/